Webinar Desensitization December 2019 3

Global’s Affiliate Model Working together to dramatically improve the lives of people with Down syndrome

Anna and John J. Sie are the founding donors of the Global Down Syndrome Foundation (Global) and Global’s Affiliates. The Sies’ aim was to reverse the terrible disparity of Down syndrome research funding at the National Institutes of Health (NIH) and to quickly and dramatically improve health outcomes for those with the condition.

We support over:


The Sies' Vision

The Sies understood that one entity could not do it all. They proceeded to invest their cable TV-acquired wealth into Global and the following Affiliates with three tenants:

  1. Work closely together to benefit people with Down syndrome
  2. Pursue excellence and measureable outcomes
  3. Be Self-Sustaining financially

Delivering on life-changing and life-saving research and medical care:

AcceptAbility Andy Grammer
Global Down Syndrome Foundation

The largest research non-profit in the U.S. working to save lives, elongate life and dramatically improve health outcomes for people with Down syndrome.

Affiliates Crnic 01 Kelly Sullivan(1)
Linda Crnic Institute for Down Syndrome

The largest scientific institute in the world dedicated to improving the lives of people with Down syndrome through advanced biomedical research. 

Sie Center Francis Hickey MD
Anna & John J. Sie Center for Down Syndrome

One of the largest pediatric Down syndrome centers in the world providing transformative and life-saving medical care.

Crnic Institute Huntington Potter
University of Colorado Alzheimer’s & Cognition Center

With more than fifty professionals, the center is providing innovative research and patient care while looking at Down syndrome and Alzheimer’s disease as two-sides of the same coin.

Adult Down Syndrome Clinic Group Shot
Global Adult Medical Center for Down Syndrome

Global is working with Denver Health to pilot a medical center for adults with Down syndrome. The goal is to create a permanent, world-class center that will open in 2021.